Quimby S R, Markowitz H, Winkelmann R K
Acta Derm Venereol. 1980;60(6):485-90.
Psoriatic patients were examined for serologic evidence of streptococcal infections by using antideoxyribonuclease B (ADB), which has been shown to be a more sensitive screening tool than antistreptolysin O (ASO) for detecting such evidence in other clinical circumstances. Antistreptococcal antibody titers (ASO and ADB) of 71 patients with psoriasis vulgaris, 7 with guttate psoriasis, and 6 with erythrodermic psoriasis were compared with ASO and ADB antibody titers of 25 non-psoriatic dermatologic patients hospitalized at the same time and of an adult group that was used as a control for the test itself. Thirty-six of 71 patients with psoriasis vulgaris had elevated titers of ADB or ASO (41% vs. 15%). Compared with control values the ADB titers were significantly higher in patients with psoriasis vulgaris (P less than 0.02) and patients with guttate psoriasis (P less than 0.05). The ASO titers were significantly higher in patients with psoriasis vulgaris than in controls (P less than 0.04). Within the group with psoriasis vulgaris, ADB titers were significantly higher than ASO titers (P less than 0.01). Among patients with psoriasis vulgaris, histories of sudden flares of psoriasis and early recurrences of psoriasis after previous successful hospital treatment, family histories of psoriasis, and histories of potential streptococcal infections were more frequent in those with elevated antistreptococcal antibodies.
通过使用抗脱氧核糖核酸酶B（ADB）对银屑病患者进行链球菌感染的血清学证据检测，在其他临床情况下，ADB已被证明是一种比抗链球菌溶血素O（ASO）更敏感的筛查工具。将71例寻常型银屑病患者、7例点滴状银屑病患者和6例红皮病型银屑病患者的抗链球菌抗体滴度（ASO和ADB）与同期住院的25例非银屑病皮肤病患者以及用作检测自身对照的成人组的ASO和ADB抗体滴度进行比较。71例寻常型银屑病患者中有36例ADB或ASO滴度升高（41%对15%）。与对照值相比，寻常型银屑病患者（P<0.02）和点滴状银屑病患者（P<0.05）的ADB滴度显著更高。寻常型银屑病患者的ASO滴度显著高于对照组（P<0.04）。在寻常型银屑病组中，ADB滴度显著高于ASO滴度（P<0.01）。在寻常型银屑病患者中，抗链球菌抗体升高的患者中，银屑病突然发作史、既往成功住院治疗后银屑病早期复发史、银屑病家族史和潜在链球菌感染史更为常见。
