Hayakawa C K, Spanier J, Bevilacqua F, Dunn A K, You J S, Tromberg B J, Venugopalan V
Opt Lett. 2001 Sep 1;26(17):1335-7. doi: 10.1364/ol.26.001335.
We introduce a novel and efficient method to provide solutions to inverse photon migration problems in heterogeneous turbid media. The method extracts derivative information from a single Monte Carlo simulation to permit the rapid determination of rates of change in the detected photon signal with respect to perturbations in background tissue optical properties. We then feed this derivative information to a nonlinear optimization algorithm to determine the optical properties of the tissue heterogeneity under examination. We demonstrate the use of this approach to solve rapidly a two-region inverse problem of photon migration in the transport regime, for which diffusion-approximation-based approaches are not applicable.
我们介绍了一种新颖且高效的方法，用于解决异质浑浊介质中的逆光子迁移问题。该方法从单次蒙特卡罗模拟中提取导数信息，以便快速确定检测到的光子信号相对于背景组织光学特性扰动的变化率。然后，我们将此导数信息输入到非线性优化算法中，以确定所研究的组织异质性的光学特性。我们展示了这种方法在传输区域中快速解决光子迁移的双区域逆问题的应用，而基于扩散近似的方法不适用于此问题。
