Guan Shuo, Li Yuhang, Gao Yuanyuan, Luo Yuxi, Zhao Hubin, Yang Dalin, Li Rihui
Centre for Cognitive and Brain Sciences, Institute of Collaborative Innovation, University of Macau, Taipa, Macau SAR, China.
Department of Psychology, Faculty of Social Science, University of Macau, Taipa, Macau SAR, China.
Sensors (Basel). 2025 Mar 25;25(7):2040. doi: 10.3390/s25072040.
Continuous wave-diffuse optical tomography (CW-DOT) has emerged as a promising non-invasive neuroimaging technique for assessing brain function. Its ability to provide brain mapping with high spatial resolution over traditional functional near-infrared spectroscopy (fNIRS) has garnered significant interest in clinical and cognitive neuroscience. In this review, we critically summarized the hardware, reconstruction algorithms, and applications of CW-DOT for human brain mapping, providing an up-to-date overview and guidelines for future studies to conduct CW-DOT studies. ScienceDirect, PubMed, Web of Science, and IEEE Xplore databases were searched from their inception up to 1 July 2024. A total of 83 articles were included in the final systematic review. The review focused on existing hardware systems, reconstruction algorithms for CW-DOT, and the applications of CW-DOT in both clinical settings and cognitive neuroscience. Finally, we highlighted current challenges and potential directions of CW-DOT in future research, including the absence of standardized protocols and a pressing need for enhanced quantitative precision. This review underscores the sophisticated capabilities of CW-DOT systems, particularly in the realm of human brain imaging. Extensive clinical and neuroscience research has attested to the technique's anatomical precision and reliability, establishing it as a potent instrument in research and clinical practice.
连续波扩散光学断层扫描（CW-DOT）已成为一种很有前景的用于评估脑功能的非侵入性神经成像技术。与传统的功能近红外光谱（fNIRS）相比，它能够提供具有高空间分辨率的脑图谱，这在临床和认知神经科学领域引起了极大的兴趣。在这篇综述中，我们批判性地总结了用于人类脑图谱的CW-DOT的硬件、重建算法和应用，为未来开展CW-DOT研究提供了最新的概述和指导方针。我们检索了ScienceDirect、PubMed、Web of Science和IEEE Xplore数据库，检索时间跨度从各数据库创建至2024年7月1日。最终的系统综述共纳入83篇文章。该综述聚焦于现有的硬件系统、CW-DOT的重建算法以及CW-DOT在临床环境和认知神经科学中的应用。最后，我们强调了CW-DOT在未来研究中的当前挑战和潜在方向，包括缺乏标准化方案以及迫切需要提高定量精度。这篇综述强调了CW-DOT系统的复杂能力，特别是在人类脑成像领域。广泛的临床和神经科学研究已经证明了该技术的解剖学精度和可靠性，使其成为研究和临床实践中的有力工具。
