Choudhury Monisha, Kahkashan Eram, Choudhury Subhasish Roy
Department of Pathology, Lady Hardinge Medical College, New Delhi.
Trop Gastroenterol. 2007 Apr-Jun;28(2):81-2.
Mucormycosis is a rare opportunistic fungal infection. It occurs mainly in immunocompromised patients and is usually fatal in children. This fungus can affect central nervous system, nasopharynx, lungs, skin and gastrointestinal tract. It invades the blood vessels and causes thrombosis, leading to infarction of the surrounding tissues. The diagnosis depends mainly on histopathological examination and demonstration of the fungus in the tissue sections, therefore a high index of suspicion and early exploration is required. We report a case of malnourished child who presented with perforation peritonitis. Investigations revealed very low total serum proteins and raised serum creatinine and blood urea levels. On exploratory laparotomy three perforations were located in the gastrointestinal tract. Histopathlogical examination of the perforation edge sections showed characteristic fungal hyphae confirming the diagnosis of gastrointestinal mucormycosis.
毛霉病是一种罕见的机会性真菌感染。它主要发生在免疫功能低下的患者中，在儿童中通常是致命的。这种真菌可影响中枢神经系统、鼻咽、肺、皮肤和胃肠道。它侵入血管并导致血栓形成，进而导致周围组织梗死。诊断主要依靠组织病理学检查以及在组织切片中发现真菌，因此需要高度的怀疑指数和早期探查。我们报告一例营养不良儿童，其表现为穿孔性腹膜炎。检查发现血清总蛋白极低，血清肌酐和血尿素水平升高。在剖腹探查术中，在胃肠道发现了三个穿孔。穿孔边缘切片的组织病理学检查显示有特征性的真菌菌丝，确诊为胃肠道毛霉病。
