Patel Trupti, Bansal Rimpi, Trivedi Priti, Patel S M, Bhullar Chetna
Department of Pathology, The Gujarat Cancer and Research Institute, M.P. Shah Cancer Hospital, Ahmedabad, Gujarat.
Indian J Pathol Microbiol. 2005 Jul;48(3):405-7.
Mucormycosis is an uncommon fungal infection, occurring mainly in patients with acidosis, chronic illnesses and malignancies. The most frequent site of involvement in patients of hematological malignancies is the respiratory tract. Isolated subcutaneous localization of mucormycosis in such patients is extremely rare. We report a case of a young patient of non-Hodgkin's lymphoma on chemotherapy who presented with a subcutaneous swelling on the anterior aspect of right thigh. Fine needle aspiration cytology (FNAC) smears from the swelling revealed numerous characteristic broad, irregularly contoured and pleomorphic hyphae of mucormycosis. This fungus seldom grows in culture and confirmation of the diagnosis depends on cytological or histological examination of infected tissues. Our case report documents a rare site of isolated mucormycosis infection and emphasizes the role of FNAC as a simple, rapid, accurate, and useful method of diagnosing fungal infections.
毛霉病是一种罕见的真菌感染,主要发生于酸中毒、慢性病和恶性肿瘤患者。血液系统恶性肿瘤患者最常受累的部位是呼吸道。此类患者中毛霉病孤立性皮下定位极为罕见。我们报告一例接受化疗的非霍奇金淋巴瘤年轻患者,其右大腿前侧出现皮下肿胀。对该肿胀部位进行细针穿刺抽吸细胞学检查(FNAC)涂片,发现了许多具有特征性的毛霉病宽而不规则轮廓及多形性菌丝。这种真菌很少在培养中生长,诊断的确立依赖于对感染组织的细胞学或组织学检查。我们的病例报告记录了罕见的孤立性毛霉病感染部位,并强调了FNAC作为诊断真菌感染的一种简单、快速、准确且有用方法的作用。