Nolan J C, Gathright C E, Radvany C H, Barrett R J, Sancilio L F
Department of Pharmacology, A.H. Robins Co., Richmond, VA 23220.
Pharmacol Res. 1991 Dec;24(4):377-83. doi: 10.1016/1043-6618(91)90042-v.
Adjuvant-induced arthritis in rats was attenuated by the therapeutic administration of carbonic anhydrase inhibitors. Female Lewis rats with established disease were treated daily (day 18 through day 50) with various carbonic anhydrase inhibitors; oedema and joint integrity (X-ray) were determined post-treatment. Acetazolamide, ethoxzolamide, methazolamide, and dichlorphenamide reduced paw oedema and attenuated the deterioration of the joints of rats with adjuvant arthritis. However, no carbonic anhydrase inhibitor tested possessed significant, acute, anti-inflammatory activity in the carrageenan-paw oedema test. The activity of carbonic anhydrase inhibitors in the chronic model of inflammation may be due to their reported inhibition of bone resorption.
碳酸酐酶抑制剂的治疗性给药可减轻大鼠佐剂性关节炎。对患有已确诊疾病的雌性Lewis大鼠每日（第18天至第50天）给予各种碳酸酐酶抑制剂；治疗后测定水肿和关节完整性（X线）。乙酰唑胺、乙氧唑胺、甲醋唑胺和二氯苯酰胺可减轻爪部水肿，并减轻佐剂性关节炎大鼠关节的恶化。然而，在角叉菜胶致爪部水肿试验中，所测试的碳酸酐酶抑制剂均不具有显著的急性抗炎活性。碳酸酐酶抑制剂在慢性炎症模型中的活性可能归因于其报道的对骨吸收的抑制作用。
