患者对碳酸酐酶抑制剂的耐受性。

Patient tolerance to carbonic anhydrase inhibitors.

作者信息

Lichter P R, Newman L P, Wheeler N C, Beall O V

出版信息

Am J Ophthalmol. 1978 Apr;85(4):495-502. doi: 10.1016/s0002-9394(14)75247-x.

Abstract

We evaluated carbonic anhydrase inhibitors in a crossover study with a placebo and random allocation of treatment administration. Drugs evaluated included acetazolamide tablets and Sequels, dichlorphenamide, ethoxzolamide, methazolamide, and an ascorbic acid placebo. The best tolerated drug was acetazolamide Sequels. Methazolamide was next. The least tolerated drugs were ethoxzolamide, acetazolamide tablets, and dichlorphenamide.

摘要

我们在一项交叉研究中评估了碳酸酐酶抑制剂，该研究采用安慰剂并随机分配治疗用药。评估的药物包括乙酰唑胺片和缓释制剂、双氯非那胺、乙氧唑胺、甲醋唑胺以及一种抗坏血酸安慰剂。耐受性最佳的药物是乙酰唑胺缓释制剂。其次是甲醋唑胺。耐受性最差的药物是乙氧唑胺、乙酰唑胺片和双氯非那胺。