Structure elucidation of a dihydropyranone from Tapinanthus dodoneifolius.

作者信息

Ouedraogo Maurice, Carreyre Hélène, Vandebrouck Clarisse, Bescond Jocelyn, Raymond Guy, Guissou Innocent-Pierre, Cognard Christian, Becq Frédéric, Potreau Daniel, Cousson Alain, Marrot Jérôme, Coustard Jean-Marie

机构信息

Institut de Physiologie et Biologie Cellulaires, Université de Poitiers, CNRS/UMR 6187, 40 Avenue du Recteur Pineau, F-86022, Poitiers Cedex, France.

出版信息

J Nat Prod. 2007 Dec;70(12):2006-9. doi: 10.1021/np070355x. Epub 2007 Dec 6.

DOI:10.1021/np070355x

PMID:18052322

Abstract

A new dihydropyranone, ( R)-6-[( S)-2-hydroxy-4-(4-hydroxyphenyl)butyl]-5,6-dihydropyran-2-one ( 1), was isolated from Tapinanthus dodoneifolius. The structure was determined from spectroscopic and X-ray crystallographic analysis. Compound 1 (named dodoneine) showed a relaxing effect on preconstricted rat aortic rings (IC 50 of 81.4 +/- 0.9 microM).

摘要