Labrecque G, Bélanger P M
Laboratoire de chronopharmacologie, Université Laval, Québec, Canada.
Pharmacol Ther. 1991 Oct;52(1):95-107. doi: 10.1016/0163-7258(91)90088-4.
Studies carried out in the last 20 years indicated that biological rhythms can be detected in the pharmacokinetics of most classes of drugs. These time-dependent variations could be due to parallel changes in the physiological functions and variables involved in the absorption, distribution, metabolism and excretion of drugs. A review of the data available suggests that the peak and trough values of these functions and variables do not occur at the same hour of the day in every factor involved in drug disposition. This information could be used to predict the time-dependent changes in the pharmacokinetics. The presence of circadian variations in the kinetics of drugs raise the rather old question: "When to administer drug?"
过去20年开展的研究表明，在大多数种类药物的药代动力学中可检测到生物节律。这些时间依赖性变化可能归因于药物吸收、分布、代谢和排泄所涉及的生理功能及变量的平行变化。对现有数据的回顾表明，这些功能和变量的峰值和谷值并非在药物处置所涉及的每个因素中的同一天的同一时刻出现。该信息可用于预测药代动力学中随时间的变化。药物动力学中昼夜变化的存在提出了一个由来已久的问题：“何时给药？”
