Schellhaas Ulrike, Gerber Wolfgang, Hammes Stefan, Ockenfels Hans M
Department of Dermatology and Allergy, Klinikum Stadt Hanau, Hanau, Germany.
Dermatol Surg. 2008 Jan;34(1):67-72. doi: 10.1111/j.1524-4725.2007.34010.x. Epub 2007 Dec 5.
Verrucae vulgaris can be removed in a variety of ways but a specific therapy of choice has not yet been developed. Doctors are faced with a challenge, especially in the treatment of recalcitrant warts. It has been suggested that the success of pulsed dye laser treatment lies in the fact that warts contain an increased number of dilated blood vessels.
Seventy-three patients (42 female, 31 male) with verrucae vulgaris on their hands or feet (1:1.5) were given a maximum of 12 treatments with a flashlamp-pumped pulsed dye laser every 2 weeks over a period of 24 weeks until complete clearance had been achieved. A laser energy density of 8 to 12 J/cm2 with a spot size of 5 mm and a pulse duration of 450 microsec were used. The minimum follow-up period was 6 months.
A total of 15.1% patients achieved complete clearance after 1 session and 47.9% after 2 to 5 sessions, resulting in a remission of 63.0% patients after a maximum of 5 treatment sessions. A remission of 23.3% patients was seen after 6 to 9 treatments and a total of 89.0% of patients showed remission after a maximum of 10 sessions. Only three patients (4.1%) failed and five patients (6.9%) stopped the treatment on account of pain/noncompliance. Only one patient, from a group of patients treated between January 2003 and April 2004, has relapsed.
Pulsed dye laser treatment is effective and safe in the treatment of recalcitrant viral warts.
寻常疣可以通过多种方式去除,但尚未开发出一种特定的首选治疗方法。医生面临着挑战,尤其是在治疗顽固性疣方面。有人认为脉冲染料激光治疗的成功在于疣中扩张血管数量增加这一事实。
73例(42例女性,31例男性)手部或足部患有寻常疣(比例为1:1.5)的患者,每2周接受一次闪光灯泵浦脉冲染料激光治疗,最多治疗12次,为期24周,直至完全清除。使用的激光能量密度为8至12 J/cm²,光斑尺寸为5 mm,脉冲持续时间为450微秒。最短随访期为6个月。
共有15.1%的患者在1次治疗后实现完全清除,47.9%的患者在2至5次治疗后实现清除,因此最多5次治疗后63.0%的患者病情缓解。6至9次治疗后23.3%的患者病情缓解,最多10次治疗后89.0%的患者病情缓解。只有3例患者(4.1%)治疗失败,5例患者(6.9%)因疼痛/不配合而停止治疗。在2003年1月至2004年4月期间接受治疗的一组患者中,只有1例复发。
脉冲染料激光治疗顽固性病毒性疣有效且安全。