寻常疣：脉冲染料激光疗法与水杨酸+脉冲染料激光疗法的比较

Akarsu S, Ilknur T, Demirtaşoglu M, Ozkan S

Department of Dermatology, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey.

J Eur Acad Dermatol Venereol. 2006 Sep;20(8):936-40. doi: 10.1111/j.1468-3083.2006.01679.x.

BACKGROUND

In recent years, lasers have been used in verruca therapy and some successful results have been obtained in some types of verruca. In some of these laser studies, peeling processes have been used to increase penetration.

OBJECTIVE

This study aimed to compare the effects of pulsed dye laser (PDL) therapy with the effects of PDL therapy following salicylic acid (SA) application. The purpose of the SA application is to increase the laser penetration by decreasing the hyperkeratosis of verruca vulgaris.

METHODS

This controlled study included 66 lesions from 19 patients enrolled in the study. PDL was applied to 33 lesions following 30% SA application twice a day for 5 days, and the remaining 33 lesions underwent PDL therapy. PDL was administered in both groups at 4-week intervals varying from one to five sessions. In the comparison of these two groups, the changes in verruca dimensions were recorded in width x length x height (mm3), and the results of the therapy were evaluated statistically.

RESULTS

In both PDL and SA + PDL groups, the regressions observed in the size of the lesions were statistically significant at the end of the fifth session compared with those observed at the onset of the therapy (P < 0.05). At the end of the fifth session, the difference between the two groups was not statistically significant (P = 0.451); however, the clearance rate in the SA + PDL group was more statistically significant than that in the PDL group after the second session (P = 0.049). The complete clearance rate in the SA + PDL group was 54.6% after the second session, but 66.4% in the PDL group only after the fifth session. Complete clearance in the SA + PDL group was observed after 2.2 sessions, and in the PDL group after 3.1 sessions (P < 0.05).

CONCLUSIONS

Although there was no difference between the clearance rate of the SA + PDL group and that of the PDL group after the fifth session, adding SA to PDL decreased the number of sessions to a large extent.

背景

近年来，激光已被用于疣的治疗，并且在某些类型的疣中取得了一些成功的结果。在其中一些激光研究中，采用了剥脱过程来增加穿透力。

目的

本研究旨在比较脉冲染料激光（PDL）治疗与水杨酸（SA）应用后PDL治疗的效果。应用SA的目的是通过减少寻常疣的角化过度来增加激光穿透力。

方法

这项对照研究纳入了19名参与研究患者的66个皮损。对33个皮损在每天两次应用30% SA共5天后进行PDL治疗，其余33个皮损接受PDL治疗。两组均每隔4周进行PDL治疗，治疗次数为1至5次。在比较这两组时，记录疣在宽度×长度×高度（mm³）方面尺寸的变化，并对治疗结果进行统计学评估。

结果

在PDL组和SA + PDL组中，与治疗开始时相比，在第五次治疗结束时观察到的皮损大小消退在统计学上均有显著意义（P < 0.05）。在第五次治疗结束时，两组之间的差异无统计学意义（P = 0.451）；然而，在第二次治疗后，SA + PDL组的清除率在统计学上比PDL组更显著（P = 0.049）。SA + PDL组在第二次治疗后的完全清除率为54.6%，但PDL组仅在第五次治疗后为66.4%。SA + PDL组在2.2次治疗后观察到完全清除，PDL组在3.1次治疗后观察到完全清除（P < 0.05）。