大鼠雄激素组织染色质中的受体蛋白。
Acceptor proteins in rat androgenic tissue chromatin.
作者信息
Klyzsejko-Stefanowicz L, Chiu J F, Tsai Y H, Hnilica L S
出版信息
Proc Natl Acad Sci U S A. 1976 Jun;73(6):1954-8. doi: 10.1073/pnas.73.6.1954.
Abstract
Fractionation of chromatin into urea-soluble chromosomal nonhistone proteins (UP), histones (HP), and DNA-associated nonhistone proteins (NP) revealed that the NP fraction from testicular and prostatic chromatin contains organ-specific acceptors for complexes of 5alpha-dihydrotestosterone (17beta-hydroxy-5alpha-androstan-3-one) and its receptor. This acceptor capacity of androgenic tissue chromatin could be transferred to chromatins from non-target tissues with the NP fraction of DNA-associated proteins. Phosphorylation of chromatin enhanced its hormone-receptor binding capacity.
摘要
将染色质分离为尿素可溶性染色体非组蛋白（UP）、组蛋白（HP）和DNA相关非组蛋白（NP），结果显示，睾丸和前列腺染色质的NP组分含有5α-二氢睾酮（17β-羟基-5α-雄甾烷-3-酮）及其受体复合物的器官特异性受体。雄激素组织染色质的这种受体能力可通过DNA相关蛋白的NP组分转移至非靶组织的染色质。染色质的磷酸化增强了其激素-受体结合能力。
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本文引用的文献
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