Bracha H S
Schizophr Bull. 1991;17(4):551-3. doi: 10.1093/schbul/17.4.551.
During normal development of the fetal brain, the left hemisphere lags behind the right hemisphere in intrauterine growth, causing the left hemisphere to be smaller than the right hemisphere throughout the early and mid-prenatal period. By the end of the second trimester, the right hemisphere has achieved almost full-term size; thus second-trimester injuries affecting neurons, that is, anoxic, ischemic, toxic, or infectious insults that are systemic and bilateral, will affect the left hemisphere more than the right hemisphere. While other explanations for brain asymmetries in schizophrenia have been proposed, the embryological literature is consistent with the hypothesis that a prenatal injury may be one etiological factor in producing the structural brain asymmetries seen in psychotic adult patients.
在胎儿大脑的正常发育过程中，左半球在子宫内生长方面落后于右半球，导致左半球在整个产前早期和中期都比右半球小。到妊娠中期结束时，右半球已达到几乎足月的大小；因此，影响神经元的妊娠中期损伤，即全身性和双侧性的缺氧、缺血、中毒或感染性损伤，对左半球的影响将大于右半球。虽然已经提出了关于精神分裂症大脑不对称性的其他解释，但胚胎学文献与这样的假设一致，即产前损伤可能是导致成年精神病患者出现大脑结构不对称的一个病因因素。
