NMDA受体的老化：从老鼠的视角来看
Aging of the NMDA receptor: from a mouse's point of view.
作者信息
Magnusson Kathy R
机构信息
Department of Biomedical Sciences, College of Veterinary Medicine, Healthy Aging Program, Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA ■ Tel.: +1 541 737 6923 ■ ■
出版信息
Future Neurol. 2012 Sep;7(5):627-637. doi: 10.2217/fnl.12.54.
Abstract
Our elderly population is growing and declines in cognitive abilities, such as memory, can be costly, because it can interfere with a person's ability to live independently. The NMDA receptor is very important for many different forms of memory and this receptor is negatively affected by aging. This review examines the progress that has been made recently in characterizing selective vulnerabilities of different subunits and splice variants of the NMDA receptor to normal aging in C57BL/6 mice. Evidence is also presented for changes in the relationships of NMDA receptors to plasticity across aging. Recent interventions show that enhancing NMDA receptors in aged individuals is associated with improvements in memory, but mouse models of neurodegenerative diseases suggest that finding the right balance between too little and too much NMDA receptor activity will be the key to enhancing memory without inducing pathology.
摘要
我们的老年人口正在增长，认知能力的下降，如记忆力衰退，代价高昂，因为它会干扰一个人独立生活的能力。N-甲基-D-天冬氨酸（NMDA）受体对多种不同形式的记忆非常重要，并且该受体受到衰老的负面影响。本综述考察了最近在表征C57BL/6小鼠中NMDA受体不同亚基和剪接变体对正常衰老的选择性易损性方面所取得的进展。还提供了证据证明NMDA受体与衰老过程中可塑性之间关系的变化。最近的干预措施表明，增强老年个体的NMDA受体会改善记忆力，但神经退行性疾病的小鼠模型表明，在NMDA受体活性过少和过多之间找到正确的平衡将是在不诱发病变的情况下增强记忆力的关键。
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本文引用的文献
1
Reelin-mediated Signaling during Normal and Pathological Forms of Aging.衰老的正常和病理形式中的 Reelin 介导的信号转导。
Aging Dis. 2010 Aug;1(1):12-29. Epub 2010 Jun 4.
2
Restoration of synaptic plasticity and learning in young and aged NCAM-deficient mice by enhancing neurotransmission mediated by GluN2A-containing NMDA receptors.通过增强含有 GluN2A 的 NMDA 受体介导的神经递质传递，恢复年轻和老年 NCAM 缺陷型小鼠的突触可塑性和学习能力。
J Neurosci. 2012 Feb 15;32(7):2263-75. doi: 10.1523/JNEUROSCI.5103-11.2012.
3
Reducing expression of GluN1(0XX) subunit splice variants of the NMDA receptor interferes with spatial reference memory.减少 NMDA 受体 GluN1(0XX)亚基剪接变异体的表达会干扰空间参照记忆。
Behav Brain Res. 2012 May 1;230(2):317-24. doi: 10.1016/j.bbr.2012.02.014. Epub 2012 Feb 16.
4
Dissecting the age-related decline on spatial learning and memory tasks in rodent models: N-methyl-D-aspartate receptors and voltage-dependent Ca2+ channels in senescent synaptic plasticity.解析啮齿动物模型中与年龄相关的空间学习和记忆任务下降：衰老突触可塑性中的 N-甲基-D-天冬氨酸受体和电压依赖性 Ca2+通道。
Prog Neurobiol. 2012 Mar;96(3):283-303. doi: 10.1016/j.pneurobio.2012.01.007. Epub 2012 Jan 28.
5
Timing of onset of cognitive decline: results from Whitehall II prospective cohort study.认知能力下降的发病时间：来自 Whitehall II 前瞻性队列研究的结果。
BMJ. 2012 Jan 5;344:d7622. doi: 10.1136/bmj.d7622.
6
Changes in cognition.认知变化。
Neurobiol Aging. 2011 Dec;32 Suppl 1(0 1):S58-63. doi: 10.1016/j.neurobiolaging.2011.09.010.
7
Rescue of cognitive aging by long-lasting environmental enrichment exposure initiated before median lifespan.长期环境丰富暴露可挽救中年寿命前认知老化。
Neurobiol Aging. 2012 May;33(5):1005.e1-10. doi: 10.1016/j.neurobiolaging.2011.09.028. Epub 2011 Oct 27.
8
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Semin Cell Dev Biol. 2011 Jul;22(5):521-9. doi: 10.1016/j.semcdb.2011.06.003. Epub 2011 Jun 17.
9
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J Gerontol A Biol Sci Med Sci. 2011 Jun;66(6):607-19. doi: 10.1093/gerona/glr024. Epub 2011 Mar 31.
10
Changes in expression of splice cassettes of NMDA receptor GluN1 subunits within the frontal lobe and memory in mice during aging.在衰老过程中，小鼠额叶 NMDA 受体 GluN1 亚基剪接盒的表达变化与记忆
Behav Brain Res. 2011 Sep 12;222(1):122-33. doi: 10.1016/j.bbr.2011.03.045. Epub 2011 Apr 2.
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