意大利人源和动物源肠炎沙门氏菌鼠伤寒血清型中的抗菌药物耐药性

Antimicrobial resistance in Salmonella enterica serovar Typhimurium from human and animal sources in Italy.

作者信息

Graziani C, Busani L, Dionisi A M, Lucarelli C, Owczarek S, Ricci A, Mancin M, Caprioli A, Luzzi I

机构信息

Istituto Superiore di Sanità, Dipartimento di Sanità Alimentare ed Animale, Viale Regina Elena, 299 I-00161 Rome, Italy.

出版信息

Vet Microbiol. 2008 Apr 30;128(3-4):414-8. doi: 10.1016/j.vetmic.2007.10.017. Epub 2007 Oct 23.

DOI:10.1016/j.vetmic.2007.10.017

PMID:18054179

Abstract

Salmonella Typhimurium strains isolated in Italy in the period 2002-2004 from human and animal sources were examined for their antimicrobial susceptibility. Resistance to tetracycline (T, 73.6%), sulfonamides (Su, 73.3%), ampicillin (A, 67.6%), streptomycin (S, 65.4%) and chloramphenicol (C, 32.3%) were frequently observed. Resistance to ciprofloxacin was only observed in a swine strain, but most human strains resistant to nalidixic acid showed reduced susceptibility to that drug (MIC > or = 0.125 mg/l). Overall, 64% of the strains were resistant to four or more drugs. The most common resistance profiles were ACSSuT, prevalent in strains belonging phage type DT104 and ASSuT, prevalently associated with strains unable to be typed.

摘要

对2002年至2004年期间在意大利从人和动物源分离出的鼠伤寒沙门氏菌菌株进行了抗菌药敏检测。经常观察到对四环素（T，73.6%）、磺胺类药物（Su，73.3%）、氨苄青霉素（A，67.6%）、链霉素（S，65.4%）和氯霉素（C，32.3%）的耐药性。仅在一株猪源菌株中观察到对环丙沙星的耐药性，但大多数对萘啶酸耐药的人源菌株对该药物的敏感性降低（MIC≥0.125mg/l）。总体而言，64%的菌株对四种或更多药物耐药。最常见的耐药谱为ACSSuT，在噬菌体类型DT104的菌株中普遍存在，以及ASSuT，主要与无法分型的菌株相关。