大脑中的水运动：水通道蛋白的作用。
Water movements in the brain: role of aquaporins.
作者信息
Tait Matthew J, Saadoun Samira, Bell B Anthony, Papadopoulos Marios C
机构信息
Academic Neurosurgery Unit, St. George's University of London, Cranmer Terrace, Tooting, London SW17 0RE, UK.
出版信息
Trends Neurosci. 2008 Jan;31(1):37-43. doi: 10.1016/j.tins.2007.11.003. Epub 2007 Dec 4.
About 80% of the brain is water. This review discusses the importance of the three brain water-channel proteins (AQP1, AQP4, AQP9) in brain physiology. AQP1 is expressed in the choroid plexus and participates in forming cerebrospinal fluid. AQP4, found in astrocyte foot processes, glia limitans and ependyma, facilitates water movement into and out of the brain, accelerates astrocyte migration and alters neuronal activity. Recently, AQP4 autoantibodies were discovered in patients with neuromyelitis optica, a demyelinating disease, and are now being used to diagnose this condition. AQP9 is present in some glia and neurons, but its function is unclear. Finally, we discuss how the discovery of AQP activators and inhibitors will be the next major step in this field.
大脑约80%是水。本综述讨论了三种脑水通道蛋白（水通道蛋白1、水通道蛋白4、水通道蛋白9）在脑生理学中的重要性。水通道蛋白1在脉络丛中表达，并参与脑脊液的形成。水通道蛋白4存在于星形胶质细胞足突、胶质界膜和室管膜中，促进水进出大脑，加速星形胶质细胞迁移并改变神经元活动。最近，在脱髓鞘疾病视神经脊髓炎患者中发现了水通道蛋白4自身抗体，目前正用于诊断该疾病。水通道蛋白9存在于一些胶质细胞和神经元中，但其功能尚不清楚。最后，我们讨论了水通道蛋白激活剂和抑制剂的发现将如何成为该领域的下一个重大进展。
Zotero 插件