衰老后期大规模脑系统的破坏。
Disruption of large-scale brain systems in advanced aging.
作者信息
Andrews-Hanna Jessica R, Snyder Abraham Z, Vincent Justin L, Lustig Cindy, Head Denise, Raichle Marcus E, Buckner Randy L
机构信息
Department of Psychology, Center for Brain Science, Harvard University, Cambridge, MA 02138, USA.
出版信息
Neuron. 2007 Dec 6;56(5):924-35. doi: 10.1016/j.neuron.2007.10.038.
Cognitive decline is commonly observed in advanced aging even in the absence of disease. Here we explore the possibility that normal aging is accompanied by disruptive alterations in the coordination of large-scale brain systems that support high-level cognition. In 93 adults aged 18 to 93, we demonstrate that aging is characterized by marked reductions in normally present functional correlations within two higher-order brain systems. Anterior to posterior components within the default network were most severely disrupted with age. Furthermore, correlation reductions were severe in older adults free from Alzheimer's disease (AD) pathology as determined by amyloid imaging, suggesting that functional disruptions were not the result of AD. Instead, reduced correlations were associated with disruptions in white matter integrity and poor cognitive performance across a range of domains. These results suggest that cognitive decline in normal aging arises from functional disruption in the coordination of large-scale brain systems that support cognition.
即使在没有疾病的情况下，认知能力下降在高龄人群中也很常见。在此，我们探讨了正常衰老可能伴随着支持高级认知的大规模脑系统协调出现紊乱性改变的可能性。在93名年龄在18至93岁的成年人中，我们证明衰老的特征是两个高阶脑系统中正常存在的功能相关性显著降低。默认网络中从前部到后部的组件随年龄增长受到的破坏最为严重。此外，通过淀粉样蛋白成像确定，在没有阿尔茨海默病（AD）病理的老年人中，相关性降低也很严重，这表明功能紊乱并非由AD导致。相反，相关性降低与白质完整性破坏以及一系列领域的认知表现不佳有关。这些结果表明，正常衰老过程中的认知能力下降源于支持认知的大规模脑系统协调功能的破坏。
Zotero 插件