Rasekh Hamid R, Nazari Pardis, Kamli-Nejad Mohammad, Hosseinzadeh Leila
School of Pharmacy, Shaheed Beheshti University of Medical Sciences, P.O. Box 14155-6153, Tehran, Iran.
J Ethnopharmacol. 2008 Feb 28;116(1):21-6. doi: 10.1016/j.jep.2007.10.030. Epub 2007 Oct 30.
Galega officinalis L. (Papilionaceae) is widely used in folk medicine as antidiabetic or for increasing lactation. There is a little information about its possible toxicity. In this study, acute and subchronic toxicity of aerial parts of Galega officinalis in Wistar rats have been evaluated. For the acute toxicity study, the animals received orally four different single dose of plant suspension and were kept under observation for 14 days. The results indicated that LD50 of Galega officinalis is higher than 5 g/kg. In the subchronic study, 48 rats were divided into four groups and were fed a diet containing 0%, 0.15%, 1.5% and 3% (w/w) of Galega officinalis. After 90 days blood and tissue samples were taken for hematological, biochemical and histopathological determinations. An increase in serum levels of cholesterol, creatine phosphokinase, lactate dehydrogenase and total and conjugated bilirubin was observed. Some parameters such as calcium, albumin, albumin/globulin ratio, hematocrit, WBC and platelet counts were decreased. In microscopic examination, sinusoidal congestion in liver and alveolar hemorrhage was observed. Other parameters showed non-significant difference between treatment and control groups. Present data suggest that liver and lung could serve as target organs in oral toxicity of this plant.
山羊豆（豆科）在民间医学中被广泛用作抗糖尿病药物或用于促进泌乳。关于其潜在毒性的信息较少。在本研究中，对Wistar大鼠评估了山羊豆地上部分的急性和亚慢性毒性。在急性毒性研究中，动物口服四种不同单剂量的植物悬浮液，并观察14天。结果表明，山羊豆的半数致死量高于5 g/kg。在亚慢性研究中，将48只大鼠分为四组，分别喂食含有0%、0.15%、1.5%和3%（w/w）山羊豆的饲料。90天后，采集血液和组织样本进行血液学、生物化学和组织病理学测定。观察到血清胆固醇、肌酸磷酸激酶、乳酸脱氢酶以及总胆红素和结合胆红素水平升高。一些参数如钙、白蛋白、白蛋白/球蛋白比值、红细胞压积、白细胞和血小板计数降低。在显微镜检查中，观察到肝脏窦状隙充血和肺泡出血。其他参数在治疗组和对照组之间无显著差异。目前的数据表明，肝脏和肺可能是该植物口服毒性的靶器官。
