对疑似处于精神病早期前驱晚期状态的人进行前驱症状治疗的急性效应。
Acute effects of treatment for prodromal symptoms for people putatively in a late initial prodromal state of psychosis.
作者信息
Ruhrmann S, Bechdolf A, Kühn K-U, Wagner M, Schultze-Lutter F, Janssen B, Maurer K, Häfner H, Gaebel W, Möller H-J, Maier W, Klosterkötter J
机构信息
Department of Psychiatry and Psychotherapy, University Hospital of the University of Cologne, Kerpener Strasse 62, 50924 Cologne, Germany.
出版信息
Br J Psychiatry Suppl. 2007 Dec;51:s88-95. doi: 10.1192/bjp.191.51.s88.
BACKGROUND
People in a putatively late prodromal state not only have an enhanced risk for psychosis but already suffer from mental and functional disturbances.
AIMS
To evaluate the acute effects of a combined supportive and antipsychotic treatment on prodromal symptoms.
METHOD
Putatively prodromal individuals were randomly assigned to a needs-focused intervention without (n=59) or with amisulpride (n=65). Outcome measures at 12-weeks effects were prodromal symptoms, global functioning and extrapyramidal side-effects.
RESULTS
Amisulpride plus the needs-focused intervention produced superior effects on attenuated and full-blown psychotic symptoms, basic, depressive and negative symptoms, and global functioning. Main side-effects were prolactin associated.
CONCLUSIONS
Coadministration of amisulpride yielded a marked symptomatic benefit. Effects require confirmation by a placebo-controlled study.
背景
处于假定的前驱期状态的人不仅患精神病的风险增加，而且已经患有精神和功能障碍。
目的
评估支持性治疗与抗精神病药物联合治疗对前驱症状的急性影响。
方法
将假定的前驱期个体随机分为无氨磺必利的以需求为导向的干预组（n = 59）和有氨磺必利的干预组（n = 65）。12周疗效的结局指标为前驱症状、整体功能和锥体外系副作用。
结果
氨磺必利加以需求为导向的干预对减轻和全面发作的精神病性症状、基本症状、抑郁症状和阴性症状以及整体功能产生了更好的效果。主要副作用与催乳素有关。
结论
联合使用氨磺必利产生了显著的症状改善。其效果需要通过安慰剂对照研究来证实。
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