全转钴胺素在孕期保持不变。孕期及产后钴胺素及其结合蛋白的纵向变化。
Holotranscobalamin remains unchanged during pregnancy. Longitudinal changes of cobalamins and their binding proteins during pregnancy and postpartum.
作者信息
Morkbak Anne L, Hvas Anne-Mette, Milman Nils, Nexo Ebba
机构信息
Dept. of Clinical Biochemistry, Aarhus University Hospital, Aarhus Sygehus, Denmark.
出版信息
Haematologica. 2007 Dec;92(12):1711-2. doi: 10.3324/haematol.11636.
PMID:18056000
Abstract
We confirm a decrease in cobalamins during pregnancy, and report that the active part of cobalamins (holotranscobalamin, holoTC) remains unchanged. The decrease in cobalamins is explained by a decreased holohaptocorrin (holoHC), suggesting that holoTC rather than cobalamins should be used as a marker of vitamin B12 deficiency during pregnancy.
摘要
我们证实孕期钴胺素水平会降低，并报告钴胺素的活性部分（全转钴胺素，holoTC）保持不变。钴胺素水平降低是由全钴胺素传递蛋白（holoHC）减少所致，这表明在孕期应使用holoTC而非钴胺素作为维生素B12缺乏的标志物。
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