Huang J Y J, Tulandi T, Holzer H, Lau N M, Macdonald S, Tan S L, Chian R C
Department of Obstetrics and Gynecology, McGill University Health Center, McGill University, Montreal, Quebec, Canada H3A 1A1.
Hum Reprod. 2008 Feb;23(2):336-9. doi: 10.1093/humrep/dem307. Epub 2007 Dec 2.
We report a novel approach of fertility preservation in a young woman with mosaic Turner syndrome. A 16-year-old female with 20% 45XO and 80% 46XX karyotype underwent laparoscopic ovarian wedge resection. Before performing ovarian tissue cryopreservation, all visible follicles on the ovarian surface were aspirated. We recovered 11 immature germinal vesicle stage oocytes, which were subjected to in vitro maturation (IVM). Eight oocytes that matured (73% maturation rate) were cryopreserved by vitrification. The combination of ovarian tissue cryobanking and immature oocyte collection from the tissue followed by IVM and vitrification of matured oocytes represent a promising approach of fertility preservation for young women with mosaic Turner syndrome.
我们报告了一种针对患有嵌合型特纳综合征的年轻女性的新型生育力保存方法。一名核型为20% 45XO和80% 46XX的16岁女性接受了腹腔镜卵巢楔形切除术。在进行卵巢组织冷冻保存之前，抽吸了卵巢表面所有可见的卵泡。我们回收了11个未成熟的生发泡期卵母细胞，并对其进行体外成熟培养（IVM）。8个成熟的卵母细胞（成熟率73%）通过玻璃化冷冻保存。卵巢组织冷冻保存、从组织中采集未成熟卵母细胞随后进行IVM以及将成熟卵母细胞玻璃化冷冻相结合，代表了一种为患有嵌合型特纳综合征的年轻女性保存生育力的有前景的方法。
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