精神分裂症认知康复的荟萃分析。
A meta-analysis of cognitive remediation in schizophrenia.
作者信息
McGurk Susan R, Twamley Elizabeth W, Sitzer David I, McHugo Gregory J, Mueser Kim T
机构信息
Dartmouth Psychiatric Research Center, 105 Pleasant Street, Concord, NH 03301, USA.
出版信息
Am J Psychiatry. 2007 Dec;164(12):1791-802. doi: 10.1176/appi.ajp.2007.07060906.
Abstract
OBJECTIVE
This study evaluated the effects of cognitive remediation for improving cognitive performance, symptoms, and psychosocial functioning in schizophrenia.
METHOD
A meta-analysis was conducted of 26 randomized, controlled trials of cognitive remediation in schizophrenia including 1,151 patients.
RESULTS
Cognitive remediation was associated with significant improvements across all three outcomes, with a medium effect size for cognitive performance (0.41), a slightly lower effect size for psychosocial functioning (0.36), and a small effect size for symptoms (0.28). The effects of cognitive remediation on psychosocial functioning were significantly stronger in studies that provided adjunctive psychiatric rehabilitation than in those that provided cognitive remediation alone.
CONCLUSIONS
Cognitive remediation produces moderate improvements in cognitive performance and, when combined with psychiatric rehabilitation, also improves functional outcomes.
摘要
目的
本研究评估了认知康复对改善精神分裂症患者认知表现、症状及社会心理功能的效果。
方法
对26项针对精神分裂症患者认知康复的随机对照试验进行了荟萃分析，共纳入1151例患者。
结果
认知康复与所有三项结果的显著改善相关，认知表现的效应量中等（0.41），社会心理功能的效应量略低（0.36），症状的效应量较小（0.28）。在提供辅助性精神科康复的研究中，认知康复对社会心理功能的影响显著强于仅提供认知康复的研究。
结论
认知康复可使认知表现得到适度改善，并且与精神科康复相结合时，还可改善功能结局。
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