对角膜微孢子虫β-微管蛋白基因的分析表明其对苯并咪唑耐药。
Analysis of the beta-tubulin gene from Vittaforma corneae suggests benzimidazole resistance.
作者信息
Franzen Caspar, Salzberger Bernd
机构信息
Department for Internal Medicine I, University of Regensburg, Franz Josef Strauss Allee 11, 93042 Regensburg. Germany.
出版信息
Antimicrob Agents Chemother. 2008 Feb;52(2):790-3. doi: 10.1128/AAC.00928-07. Epub 2007 Dec 3.
Abstract
We amplified, cloned, and sequenced the beta-tubulin gene of Vittaforma corneae, a microsporidium causing human infections. The beta-tubulin gene sequence has a substitution at Glu(198) (with glutamine), which is one of six amino acids reported to be associated with benzimidazole sensitivity. Benzimidazoles were assayed for antimicrosporidial activity and showed poor parasite inhibition.
摘要
我们扩增、克隆并测序了角膜微孢子虫（一种可导致人类感染的微孢子虫）的β-微管蛋白基因。β-微管蛋白基因序列在第198位谷氨酸（被谷氨酰胺取代）处有一个替换，这是据报道与苯并咪唑敏感性相关的六个氨基酸之一。对苯并咪唑进行了抗微孢子虫活性检测，结果显示其对寄生虫的抑制效果不佳。
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