Belobragina G V, El'nichnykh L N
Vopr Med Khim. 1977 Jul-Aug;23(4):453-8.
Accumulation of lipids, including phospholipids, in lungs was accompanied by a proliferative-cellular reaction. The proliferation of cells was caused by accumulation of lipids. One of possible mechanisms of interrelation between lipids and collagen synthesis was as follows: in silicosis degradation of macrophages was accompanied by secretion into the medium of phospholipids, which inhibited free radical oxidation; in this case the decreased formation of cytotoxic products caused the cell proliferation, including fibroblasts, which produced collagen. The importance of lipids in collagen formation was corroborated: by accumulation of lipids, which preceded the hydroxyproline increase (scleroproteins, collagen), by development of the proliferative-cellular reaction together with the higher phospholipid-hydroxyproline level as compared with control, by formation of earlier sclerosis of silicotic nodes in "condensed" silicosis with the simultaneous increase in absolute content of phospholipids and total lipids. This role of lipids was also supported by the observed correlation between the absolute contents of scleroproteins and lipids within all steps of "quartz" silicosis development.
包括磷脂在内的脂质在肺中的蓄积伴随着增殖性细胞反应。细胞增殖是由脂质蓄积引起的。脂质与胶原蛋白合成之间相互关系的一种可能机制如下：在矽肺中，巨噬细胞的降解伴随着磷脂分泌到培养基中，磷脂抑制自由基氧化；在这种情况下，细胞毒性产物形成减少导致细胞增殖，包括产生胶原蛋白的成纤维细胞。脂质在胶原蛋白形成中的重要性得到了证实：脂质蓄积先于羟脯氨酸增加（硬蛋白、胶原蛋白），增殖性细胞反应的发展以及与对照组相比更高的磷脂 - 羟脯氨酸水平，在“凝聚性”矽肺中矽结节早期硬化的形成同时磷脂和总脂质的绝对含量增加。在“石英”矽肺发展的所有阶段观察到的硬蛋白和脂质绝对含量之间的相关性也支持了脂质的这一作用。
