含有具有不对称连接基的非核苷菲结构单元的DNA。
DNA containing non-nucleosidic phenanthrene building blocks with asymmetrical linkers.
作者信息
Langenegger Simon M, Malinovskii Vladimir L, Wenger Daniel, Werder Sarah, Häner Robert
机构信息
Department of Chemistry and Biochemistry, University of Bern, Bern, Switzerland.
出版信息
Nucleosides Nucleotides Nucleic Acids. 2007;26(8-9):901-3. doi: 10.1080/15257770701506319.
PMID:18058505
Abstract
The synthesis and hybridization properties of oligonucleotides containing phenanthrene building blocks with non-nucleosidic linkers of different length are described. It was found that the length of the linkers, as well as the combination of unequal linkers can have a substantial influence on the thermal stability of the modified DNA.
摘要
本文描述了含有菲结构单元且带有不同长度非核苷连接子的寡核苷酸的合成及杂交特性。研究发现，连接子的长度以及不等长连接子的组合对修饰DNA的热稳定性会产生重大影响。
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