Kijima Akiko, Nishino Hiroshi, Umeda Jiro, Kataoka Yoko
Department of Dermatology, Osaka Prefectural Medical Center for Respiratory and Allergic Diseases.
Arerugi. 2007 Nov;56(11):1397-402.
Two cases of generalized urticaria after the dental treatment were reported. These cases had clearly positive RAST to formaldehyde, whereas skin prick testings were negative. We diagnosed them as type I allergy due to formaldehyde. Immediate type formaldehyde allergy is not widely recognized as a major allergic complication of dental treatment. Previous reports of immediate allergy to formaldehyde in dental treatment were reviewed. The characteristics are the followings, first, it tends to represent severe symptom like anaphylaxis, second, the symptom often appears a few hours later than usual cases of anaphylaxis. Allergen tests show highly positive ratio to formaldehyde RAST, whereas skin prick test often shows false negative. Assessment of specific IgE to formaldehyde is a useful and a diagnostic measurement, and is recommended in patients at risk.
报告了两例牙科治疗后出现全身性荨麻疹的病例。这些病例的甲醛变应原特异性体外放射变应原吸附试验（RAST）结果呈明显阳性，而皮肤点刺试验结果为阴性。我们将其诊断为甲醛所致的I型过敏。速发型甲醛过敏并未被广泛认为是牙科治疗的主要过敏并发症。回顾了既往关于牙科治疗中速发型甲醛过敏的报告。其特点如下：第一，倾向于表现为如过敏反应等严重症状；第二，症状通常比普通过敏反应病例出现得晚几个小时。变应原检测显示甲醛RAST的阳性率很高，而皮肤点刺试验常呈假阴性。评估针对甲醛的特异性IgE是一种有用的诊断方法，建议对有风险的患者进行检测。
