Imhof E, Wüthrich B
Allergiestation der Dermatologischen Universitätsklinik Zürich.
Schweiz Med Wochenschr. 1988 Oct 29;118(43):1568-72.
Two patients with positive formaldehyde RAST and 3 with positive phthalic anhydride RAST are described, of whom 3 presented with a typical history of occupational asthma and one had only work-related rhinitis. The fifth case with specific IgE antibodies to formaldehyde had only a domestic exposure-effect relationship; asthmatic symptoms had first started some weeks after renovation of the patient's apartment. Thus far, failing proof of specific IgE antibodies, a true allergic reaction to formaldehyde in particular has been doubted. Presenting respiratory symptoms were considered to be probably due to irritant effects. The reported cases indicate that formaldehyde and phthalic anhydride may also exert their effect through immunologic mechanisms.
本文描述了2例甲醛RAST阳性患者和3例邻苯二甲酸酐RAST阳性患者，其中3例有典型的职业性哮喘病史，1例仅有与工作相关的鼻炎。第5例对甲醛有特异性IgE抗体的患者仅存在家庭接触-效应关系；哮喘症状在患者公寓装修几周后首次出现。迄今为止，由于缺乏特异性IgE抗体的证据，人们尤其怀疑对甲醛的真正过敏反应。出现的呼吸道症状被认为可能是由于刺激作用。报告的病例表明，甲醛和邻苯二甲酸酐也可能通过免疫机制发挥作用。
