Kopp-Schneider A, Portier C J, Rippmann F
Abteilung Biostatistik, Institut für Epidemiologie und Biometrie, Deutsches Krebsforschungszentrum, Heidelberg, Germany.
Math Biosci. 1991 Jul;105(2):139-66. doi: 10.1016/0025-5564(91)90079-x.
In a previous article, a multistage model of carcinogenesis was introduced that takes into account the role of DNA damage, DNA repair, and cell replication on the incidence of malignancies. For this model the number of detectable clones of initiated cells is derived and model parameters are estimated using data arising from a two-stage skin-painting experiment in mice. The data from this experiment are interpretable in terms of the cellular events involved in initiation and promotion.
在之前的一篇文章中，引入了一种癌症发生的多阶段模型，该模型考虑了DNA损伤、DNA修复和细胞复制在恶性肿瘤发生率中的作用。对于这个模型，推导了起始细胞可检测克隆的数量，并使用来自小鼠两阶段皮肤涂抹实验的数据估计模型参数。该实验的数据可以根据起始和促进过程中涉及的细胞事件来解释。
