Portier C J, Kopp-Schneider A
Division of Biometry and Risk Assessment, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709.
Risk Anal. 1991 Sep;11(3):535-43. doi: 10.1111/j.1539-6924.1991.tb00639.x.
Mathematical models of carcinogenesis are one tool used for research into the mechanisms of carcinogenesis and for assessing risks from exposure to carcinogenic agents. Recent research into carcinogenic mechanisms has focused on the role of cell replication in fixing damage to cellular DNA and increasing the incidence of malignancies. The most commonly used multistage model of carcinogenesis does not explicitly account for DNA damage and the contribution of cell replication rates on the transformation of cells through the various stages. In this manuscript, a generalized multistage model of carcinogenesis is developed in which DNA damage, cell replication, and DNA repair are explicitly included.
癌症发生的数学模型是用于研究癌症发生机制以及评估接触致癌物质风险的一种工具。最近对致癌机制的研究集中在细胞复制在修复细胞DNA损伤和增加恶性肿瘤发生率方面的作用。最常用的癌症发生多阶段模型没有明确考虑DNA损伤以及细胞复制率在细胞通过各个阶段转变过程中的作用。在本论文中，我们建立了一个广义的癌症发生多阶段模型，其中明确纳入了DNA损伤、细胞复制和DNA修复。
