Mizgirev I V
Eksp Onkol. 1987;9(6):40-4.
A mathematical model of multistage mouse skin carcinogenesis which describes a qualitative dynamics of this phenomenon is suggested. According to this model the change in the internal state of initiated cells in promotion is determined by geometry of the Whitney catastrophe into which the surface of conditions of intact cells is transformed as a result of initiation. Molecular events underlying the convertible and unconvertible expression of a transformed phenotype by an initiated cell under the promoter action, as well as the relationship of these processes to the mechanisms of oncogene activation are discussed.
提出了一种多阶段小鼠皮肤癌发生的数学模型，该模型描述了这一现象的定性动力学。根据该模型，促癌阶段起始细胞内部状态的变化由惠特尼突变的几何形状决定，完整细胞的条件表面因起始作用而转变为该突变形状。文中讨论了在启动子作用下，起始细胞转化表型的可转换和不可转换表达背后的分子事件，以及这些过程与癌基因激活机制的关系。
