通过超临界二氧化碳气体抗溶剂法制备氨苄青霉素纳米颗粒。
Ampicillin Nanoparticles Production via Supercritical CO2 Gas Antisolvent Process.
作者信息
Esfandiari Nadia, Ghoreishi Seyyed M
机构信息
Department of Chemical Engineering, Isfahan University of Technology, 84156-83111, Isfahan, Iran.
Department of Chemical Engineering, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran.
出版信息
AAPS PharmSciTech. 2015 Dec;16(6):1263-9. doi: 10.1208/s12249-014-0264-y. Epub 2015 Mar 14.
The micronization of ampicillin via supercritical gas antisolvent (GAS) process was studied. The particle size distribution was significantly controlled with effective GAS variables such as initial solute concentration, temperature, pressure, and antisolvent addition rate. The effect of each variable in three levels was investigated. The precipitated particles were analyzed with scanning electron microscopy (SEM) and Zetasizer Nano ZS. The results indicated that decreasing the temperature and initial solute concentration while increasing the antisolvent rate and pressure led to a decrease in ampicillin particle size. The mean particle size of ampicillin was obtained in the range of 220-430 nm by varying the GAS effective variables. The purity of GAS-synthesized ampicillin nanoparticles was analyzed in contrast to unprocessed ampicillin by FTIR and HPLC. The results indicated that the structure of the ampicillin nanoparticles remained unchanged during the GAS process.
研究了通过超临界气体抗溶剂（GAS）过程对氨苄西林进行微粉化。通过有效的GAS变量（如初始溶质浓度、温度、压力和抗溶剂添加速率）显著控制了粒径分布。研究了每个变量在三个水平下的影响。用扫描电子显微镜（SEM）和Zetasizer Nano ZS对沉淀颗粒进行了分析。结果表明，降低温度和初始溶质浓度，同时提高抗溶剂速率和压力，会导致氨苄西林粒径减小。通过改变GAS有效变量，氨苄西林的平均粒径在220-430nm范围内。通过傅里叶变换红外光谱（FTIR）和高效液相色谱（HPLC）分析了GAS合成的氨苄西林纳米颗粒与未处理的氨苄西林相比的纯度。结果表明，在GAS过程中，氨苄西林纳米颗粒的结构保持不变。
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