Nunes Ana V M, Duarte Catarina M M
Requimte/CQFB, Departamento de Química, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Campus de Caparica, Caparica 2829-516, Portugal.
Instituto de Biologia Experimental e Tecnológica (IBET), Apartado 12, Oeiras 2781-901, Portugal.
Materials (Basel). 2011 Nov 16;4(11):2017-2041. doi: 10.3390/ma4112017.
The application of dense gases in particle formation processes has attracted great attention due to documented advantages over conventional technologies. In particular, the use of dense CO₂ in the process has been subject of many works and explored in a variety of different techniques. This article presents a review of the current available techniques in use in particle formation processes, focusing exclusively on those employing dense CO₂ as a solute, co-solute or co-solvent during the process, such as PGSS (Particles from gas-saturated solutions), CPF (Concentrated Powder Form), CPCSP (Continuous Powder Coating Spraying Process), CAN-BD (Carbon dioxide Assisted Nebulization with a Bubble Dryer), SEA (Supercritical Enhanced Atomization), SAA (Supercritical Fluid-Assisted Atomization), PGSS-Drying and DELOS (Depressurization of an Expanded Liquid Organic Solution). Special emphasis is given to modifications introduced in the different techniques, as well as the limitations that have been overcome.
由于与传统技术相比具有已被证实的优势,稠密气体在颗粒形成过程中的应用已引起了极大关注。特别是,在该过程中使用稠密二氧化碳一直是许多研究工作的主题,并在各种不同技术中得到探索。本文对颗粒形成过程中当前可用的技术进行了综述,专门关注那些在过程中使用稠密二氧化碳作为溶质、共溶质或共溶剂的技术,例如PGSS(气体饱和溶液制粒法)、CPF(浓缩粉末成型法)、CPCSP(连续粉末涂层喷雾法)、CAN-BD(二氧化碳辅助雾化与气泡干燥法)、SEA(超临界增强雾化法)、SAA(超临界流体辅助雾化法)、PGSS-干燥法和DELOS(膨胀液体有机溶液减压法)。特别强调了不同技术中引入的改进以及已克服的局限性。