Dostál M, Hofmannová V, Soukupová D
Institute of experimental Medicine, Czechoslovak Academy of Sciences, Prague.
Bratisl Lek Listy. 1991 Dec;92(12):589-93.
A combination of penicillin and cloxacillin (Ampiclox, Beecham Research Laboratories) is indicated for prophylaxis and treatment of bacterial infections in premature babies or neonates. We studied the functional development of the immune system in the offspring of female ICR mice administered Ampiclox on days 13-16 of pregnancy in clinically relevant doses. Immune functions were assayed after immunization with sheep red blood cells in the 5th and 10th postnatal week. Changes of hemagglutinin antibodies, delayed-type hypersensitivity and proliferative responses of spleen lymphocytes and thymocytes were observed. Ampiclox influenced humoral immunity also when administered directly to rat young on postnatal days 9-11 or 14-16. Although the clinical relevance of our experimental data remains to be established an increased sensitivity of the developing immune system to immunomodulatory effects should be considered also in the context of antimicrobial therapy. (Fig. 6, Ref. 27.)
青霉素和氯唑西林的组合制剂（氨比西林，比彻姆研究实验室）适用于早产儿或新生儿细菌感染的预防和治疗。我们研究了在妊娠第13 - 16天给予临床相关剂量氨比西林的雌性ICR小鼠后代免疫系统的功能发育。在出生后第5周和第10周用绵羊红细胞免疫后检测免疫功能。观察了血凝素抗体、迟发型超敏反应以及脾淋巴细胞和胸腺细胞增殖反应的变化。当在出生后第9 - 11天或14 - 16天直接给幼鼠施用氨比西林时，它也会影响体液免疫。尽管我们实验数据的临床相关性仍有待确定，但在抗菌治疗的背景下，也应考虑发育中的免疫系统对免疫调节作用的敏感性增加。（图6，参考文献27）
