两性霉素B治疗对小鼠免疫反应的抑制作用。
Suppression of immunological responses in mice by treatment with amphotericin B.
作者信息
Ferrante A, Rowan-Kelly B, Thong Y H
出版信息
Clin Exp Immunol. 1979 Oct;38(1):70-6.
Abstract
The polyene antibiotic amphotericin B (AmB) caused a marked suppression of the cell-mediated immune response in mice. Similar treatment did not effect the humoral antibody response. The immunosuppressive property of the drug was related to its ability to inhibit the manifestation rather than the induction phase of the delayed-type hypersensitivity response. In vitro AmB suppressed mitogen-induced lymphocyte proliferation. The drug seemed to act at the proliferative phase of the response. Results presented show that the T cell response was much more sensitive to the action of AmB than was the B cell response. During AmB chemotherapy consideration must be given to the immunosuppressive properties of this drug.
摘要
多烯抗生素两性霉素B（AmB）可显著抑制小鼠的细胞介导免疫反应。类似的处理对体液抗体反应没有影响。该药物的免疫抑制特性与其抑制迟发型超敏反应表现期而非诱导期的能力有关。在体外，AmB可抑制有丝分裂原诱导的淋巴细胞增殖。该药物似乎作用于反应的增殖期。所呈现的结果表明，T细胞反应比B细胞反应对AmB的作用更为敏感。在两性霉素B化疗期间，必须考虑该药物的免疫抑制特性。
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