Hníková O, Hejcmanová L, Marek J, Schreiberová O
Klinika dĕtí a dorostu, 3. lékarské fakulty Univerzity Karlovy.
Cesk Pediatr. 1991 Dec;46(12):537-40.
A biological method was employed for assessing the somatomedin activity (SM)-IGF I-somatomedin C: 1) in 13 10 to 23-day old children with congenital hypothyroidism (CH) before starting substitution therapy with L-thyroxine and after one month lasting therapy. SM levels were significantly lower prior to the onset of therapy than in a control group (for p less than 0.01 on 1% level). The SM levels in treated children did not differ from controls. 2) 16 children with classic phenylketonuria (PKU) were also examined of the age of 12-23 days before starting dietary treatment with restricted phenylalanine (Phe). When compared with a control group SM levels were significantly lower in the PKU group (p = 0.01 on 5% level). When stable serum Phe concentrations had been obtained, following restricted Phe intake, SM levels no longer differed from the control. However statistical correlation of Phe and SM levels was not attained.
采用生物学方法评估生长调节素活性（SM）-胰岛素样生长因子I-生长调节素C：1）对13名年龄在10至23天的先天性甲状腺功能减退症（CH）患儿，在开始用左旋甲状腺素替代治疗前及持续治疗1个月后进行评估。治疗开始前SM水平显著低于对照组（在1%水平上p<0.01）。接受治疗的患儿的SM水平与对照组无差异。2）对16名年龄在12至23天、开始限制苯丙氨酸（Phe）饮食治疗前的典型苯丙酮尿症（PKU）患儿也进行了检查。与对照组相比，PKU组的SM水平显著降低（在5%水平上p = 0.01）。在限制Phe摄入后获得稳定的血清Phe浓度时，SM水平与对照组不再有差异。然而，未实现Phe与SM水平的统计相关性。
