Mulhall Kevin J, Ghomrawi Hassan M, Bershadsky Boris, Saleh Khaled J
Department of Orthopaedic Surgery, Mater Misericordiae University Hospital, Dublin, Ireland.
J Orthop Surg Res. 2007 Dec 7;2:25. doi: 10.1186/1749-799X-2-25.
Despite the numerous outcomes measures described it remains unclear what aspects of patient outcome are important in determining actual improvement following total knee arthroplasty revisions (TKAR). We performed a prospective cohort study of TKAR to determine the components of clinical improvement and how they are related and best measured.
An improvement scale was devised utilizing data from 186 consecutive TKAR patients on SF-36 physical (PCS) and mental (MCS) components, Western Ontario and McMaster Universities Osteoarthritis (WOMAC) Index, Knee Society Score (KSS), a novel Activity Scale (AS) and a physician derived severity assessment scale performed both preoperatively and at 6 month post-operative follow-up. The change in each of these scores was analyzed using factor analysis, deriving a composite improvement scale.
All the instruments demonstrated statistically significantly better scores following TKAR (except the SF-36 MCS). Furthermore, all significant correlations between the scores were positive. Statistical factor analysis demonstrated that scores could be arranged into 4 related factor groupings with high internal consistency (Cronbach Alpha = 0.7). Factor 1 reflected patient perceived functional outcomes, Factor 2 activity levels, Factor 3 the MCS and Factor 4 the KSS.
This study demonstrates that improvement following TKAR has a multidimensional structure. The improvement scales represent a more coordinated method of the previously fragmented analysis of TKAR outcomes. This will improve assessment of the actual effectiveness of TKAR for patients and what aspects of improvement are most critical.
尽管描述了众多结局指标,但在全膝关节置换翻修术(TKAR)后,患者结局的哪些方面对确定实际改善情况很重要仍不明确。我们对TKAR进行了一项前瞻性队列研究,以确定临床改善的组成部分及其相互关系和最佳测量方法。
利用186例连续TKAR患者术前及术后6个月随访时的SF-36身体(PCS)和心理(MCS)分量表、西安大略和麦克马斯特大学骨关节炎指数(WOMAC)、膝关节协会评分(KSS)、一种新的活动量表(AS)以及医生得出的严重程度评估量表的数据,设计了一个改善量表。使用因子分析对这些分数的变化进行分析,得出一个综合改善量表。
所有工具在TKAR后均显示出统计学上显著更好的分数(除SF-36 MCS外)。此外,各分数之间的所有显著相关性均为正。统计因子分析表明,分数可分为4个具有高内部一致性的相关因子组(克朗巴哈系数=0.7)。因子1反映患者感知的功能结局,因子2反映活动水平,因子3反映MCS,因子4反映KSS。
本研究表明,TKAR后的改善具有多维结构。改善量表代表了一种比以前对TKAR结局进行分散分析更协调的方法。这将改善对TKAR对患者实际有效性的评估以及改善的哪些方面最为关键。