卵磷脂胆固醇酰基转移酶和煤中有机物质在巴尔干地方性肾病病因学中的作用：一种新假说。
The role of lecithin cholesterol acyltransferase and organic substances from coal in the etiology of Balkan endemic nephropathy: a new hypothesis.
作者信息
Pavlovic Nikola M, Orem William H, Tatu Calin A, Lerch Harry E, Bunnell Joseph E, Feder Gerald L, Kostic Emina N, Ordodi Valentin L
机构信息
Institute of Nephrology and Haemodialysis, Medical Faculty, University of Nis, Nis, Serbia.
出版信息
Food Chem Toxicol. 2008 Mar;46(3):949-54. doi: 10.1016/j.fct.2007.10.033. Epub 2007 Nov 4.
Balkan endemic nephropathy (BEN) occurs in Serbia, Bulgaria, Romania, Bosnia and Herzegovina, and Croatia. BEN has been characterized as a chronic, slowly progressive renal disease of unknown etiology. In this study, we examined the influence of soluble organic compounds in drinking water leached from Pliocene lignite from BEN-endemic areas on plasma lecithin-cholesterol acyltransferase (LCAT) activity. We found that changes for all samples were the most prominent for the dilution category containing 90% plasma and 10% of diluting media. Water samples from BEN villages from Serbia and Romania showed higher LCAT inhibiting activity (p=0.02) and (p=0.003), respectively, compared to deionised water and non-endemic water. A secondary LCAT deficiency could result from this inhibitory effect of the organic compounds found in endemic water supplies and provide an ethiopathogenic basis for the development of BEN in the susceptible population.
巴尔干地方性肾病（BEN）发生在塞尔维亚、保加利亚、罗马尼亚、波斯尼亚和黑塞哥维那以及克罗地亚。BEN的特征是一种病因不明的慢性、渐进性肾病。在本研究中，我们检测了来自BEN流行地区上新世褐煤中浸出的饮用水中的可溶性有机化合物对血浆卵磷脂胆固醇酰基转移酶（LCAT）活性的影响。我们发现，对于所有样品，在含有90%血浆和10%稀释介质的稀释类别中变化最为显著。与去离子水和非流行地区的水相比，来自塞尔维亚和罗马尼亚BEN村庄的水样分别显示出更高的LCAT抑制活性（p=0.02）和（p=0.003）。地方性供水系统中发现的有机化合物的这种抑制作用可能导致继发性LCAT缺乏，并为易感人群中BEN的发展提供病因学基础。
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