Li W J
Henan Medical University, Zhengzhou.
Zhonghua Zhong Liu Za Zhi. 1991 Jul;13(4):265-8.
The effects of selenium (Se) concentration and glutathione peroxidase (GSH-Px) activity in the development of esophageal cancer was studied. The results indicated that there were no significant differences in Se level (P greater than 0.2) and GSH-Px activity (P greater than 0.1) in the normal subjects from areas with high and low esophageal cancer mortality. In an area with high esophageal cancer mortality, the Se level and GSH-Px activity of the normal, mild hyperplasia, severe dysplasia and cancer groups decreased gradually. There was a significant difference in the erythrocyte Se concentration of the normal and severe dysplasia groups (P less than 0.03). Erythrocyte Se concentration and GSH-Px activity were significantly lower in the cancer group than in the normal group (P less than 0.001; P less than 0.03). The findings suggest that low erythrocyte Se level and GSH-Px activity were the results of carcinogenesis rather than a cause.
研究了硒（Se）浓度和谷胱甘肽过氧化物酶（GSH-Px）活性在食管癌发生发展中的作用。结果表明，食管癌高死亡率地区和低死亡率地区的正常受试者在硒水平（P>0.2）和谷胱甘肽过氧化物酶活性（P>0.1）方面无显著差异。在食管癌高死亡率地区，正常组、轻度增生组、重度发育异常组和癌症组的硒水平和谷胱甘肽过氧化物酶活性逐渐降低。正常组和重度发育异常组的红细胞硒浓度存在显著差异（P<0.03）。癌症组的红细胞硒浓度和谷胱甘肽过氧化物酶活性显著低于正常组（P<0.001；P<0.03）。研究结果表明，红细胞硒水平和谷胱甘肽过氧化物酶活性降低是致癌作用的结果而非原因。
