Van Wouwe J P, Veldhuizen M, Van der Wal W A
Department of Pediatrics, State University at Leiden, The Netherlands.
Int J Vitam Nutr Res. 1991;61(4):292-7.
In adult rats, the influence of vitamin E deficiency on zinc metabolism in general and specifically in 15 tissues was studied. After 50 days, we found evidence of vitamin E deficiency and at this time point we injected a tracer amount of 65Zn. During the next 18 days the zinc status was unaffected. The zinc metabolism, however, was altered: the apparent retention increased and the biological half life was prolonged. On day 68, the changes in various tissues varied. Some tissues were affected in zinc concentration (higher in plasma and spleen; lower in cerebrum, fur and tail), others in specific activity (higher in pancreas; lower in cerebellum). The different effects may reflect differences in tissue response on impairement, caused by vitamin E deficiency.
在成年大鼠中，研究了维生素E缺乏对整体锌代谢的影响，特别是对15种组织中锌代谢的影响。50天后，我们发现了维生素E缺乏的证据，此时我们注射了微量的65Zn。在接下来的18天里，锌状态未受影响。然而，锌代谢发生了改变：表观潴留增加，生物半衰期延长。在第68天，各种组织的变化各不相同。一些组织的锌浓度受到影响（血浆和脾脏中较高；大脑、皮毛和尾巴中较低），另一些组织的比活性受到影响（胰腺中较高；小脑中较低）。这些不同的影响可能反映了维生素E缺乏导致的组织损伤反应差异。
