Imoedemhe D A, Chan R C, Sigue A B, Pacpaco E L, Olazo A B
Human Reproductive Biology Unit, Soliman Fakeeh Hospital, Jeddah, Saudi Arabia.
Hum Reprod. 1991 Sep;6(8):1088-91. doi: 10.1093/oxfordjournals.humrep.a137489.
In this study, we report an alternative method of management of patients at a potential risk of ovarian hyperstimulation syndrome (OHSS) in an in-vitro fertilization (IVF) programme, by the use of gonadotrophin releasing hormone analogue (GnRHa). Thirty eight women considered at risk of this syndrome, having serum oestradiol greater than 4000 pg/ml following ovarian stimulation, received a GnRHa nasal spray for induction of the preovulatory endogenous luteinizing hormone surge for follicular maturation prior to oocyte recovery. Oocyte recovery (mean oocytes per cycle 18.60 +/- 4.79; range 15-35) and IVF were successfully completed in 27 cycles. Twenty six women had embryos replaced and 11 pregnancies occurred (28.9% per operation, 42.3% per replacement cycle). None of the patients developed OHSS. Where there is a risk of OHSS, the use of GnRHa to induce the preovulatory surge of endogenous luteinizing hormone for final follicular maturation provides a successful and more economical alternative to cancellation of cycles.
在本研究中，我们报告了一种在体外受精（IVF）程序中管理有卵巢过度刺激综合征（OHSS）潜在风险患者的替代方法，即使用促性腺激素释放激素类似物（GnRHa）。38名被认为有该综合征风险的女性，在卵巢刺激后血清雌二醇大于4000 pg/ml，在卵母细胞回收前接受GnRHa鼻喷雾剂以诱导排卵前内源性促黄体生成素激增，促进卵泡成熟。27个周期成功完成了卵母细胞回收（每个周期平均卵母细胞数18.60±4.79；范围15 - 35）和IVF。26名女性进行了胚胎移植，发生了11次妊娠（每次手术28.9%，每个移植周期42.3%）。没有患者发生OHSS。在存在OHSS风险的情况下，使用GnRHa诱导内源性促黄体生成素排卵前激增以实现最终卵泡成熟，为取消周期提供了一种成功且更经济的替代方法。
