Friedman A J, Juneau-Norcross M, Sedensky B
Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, MA 02115.
Hum Reprod. 1991 Sep;6(8):1125-8. doi: 10.1093/oxfordjournals.humrep.a137497.
Fifty-one infertile women were studied prospectively to assess whether intrauterine insemination (IUI) led to the development of antisperm antibodies in cervical mucus and/or serum. All women were tested for the presence of antisperm antibodies in cervical mucus and serum before and after IUI treatment. Each woman underwent between 1 and 9 cycles of IUI (mean: 4.0 cycles). Five women (9.8%) developed serum antisperm antibodies after IUI treatment. Three of 49 women (6.1%) developed cervical mucus antisperm antibodies and three other women demonstrated disappearance of antibodies following IUI treatment. IUI did not increase mucus or serum antibody titres in women who presented with antisperm antibodies. The number of IUI cycles did not correlate with the development of antisperm antibodies. We conclude that IUI increases the risk of the female partner developing systemic antisperm antibodies but the clinical significance of this finding in unclear.
对51名不孕女性进行了前瞻性研究，以评估宫腔内人工授精（IUI）是否会导致宫颈黏液和/或血清中抗精子抗体的产生。所有女性在IUI治疗前后均检测了宫颈黏液和血清中抗精子抗体的存在情况。每位女性接受了1至9个周期的IUI治疗（平均：4.0个周期）。5名女性（9.8%）在IUI治疗后产生了血清抗精子抗体。49名女性中有3名（6.1%）产生了宫颈黏液抗精子抗体，另有3名女性在IUI治疗后抗体消失。IUI并未增加存在抗精子抗体女性的黏液或血清抗体滴度。IUI周期数与抗精子抗体的产生无关。我们得出结论，IUI增加了女性伴侣产生全身性抗精子抗体的风险，但这一发现的临床意义尚不清楚。
