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2'-肼基寡核苷酸的制备及其与醛和1,3-二酮的反应。

Preparation of 2'-hydrazino oligonucleotides and their reaction with aldehydes and 1,3-diketones.

作者信息

Zatsepin Timofei S, Oretskaya Tatiana S, Gait Michael J, Stetsenko Dmitry A

机构信息

Department of Chemistry and A. N. Belozersky Institute of Physico-Chemical Biology, M. V. Lomonossov Moscow State University, Moscow, Russia.

出版信息

Nucleosides Nucleotides Nucleic Acids. 2007;26(6-7):795-8. doi: 10.1080/15257770701501625.

DOI:10.1080/15257770701501625
PMID:18066902
Abstract

Oligodeoxyribonucleotides that contain a hydrazino nucleoside, 2'-O-(2-hydrazinoethyl)uridine were prepared and shown to react with aldehydes or 1,3-diketones with the formation of hydrazones or pyrazoles, respectively. The method may be applicable for the preparation of oligonucleotide-peptide conjugates.

摘要

制备了含有肼基核苷（2'-O-(2-肼基乙基)尿苷）的寡脱氧核糖核苷酸，并证明其分别与醛或1,3-二酮反应形成腙或吡唑。该方法可能适用于制备寡核苷酸-肽缀合物。

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