[噻嗪类敏感型钠氯共转运体基因多态性与原发性高血压风险的关联]

[Association of thiazide-sensitive Na+-Cl* cotransporter gene polymorphisms with the risk of essential hypertension].

作者信息

Zhan Yi-yang, Jiang Xiao, Lin Gang, Li Jian, Sheng Hai-hui, Xiao Hua-sheng, Cheng Yun-lin, Huang Jun

机构信息

Department of Geriatrics, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210029 PR China.

出版信息

Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2007 Dec;24(6):703-5.

PMID:18067089

Abstract

OBJECTIVE

To investigate the association of thiazide-sensitive Na+ -Cl* cotransporter (TSC) gene 1784C/T and 2736G/A polymorphisms with the risk of essential hypertension (EH) in a Han nationality population.

METHODS

A community-based, case-control study including 190 EH patients and 94 sex- and age-matched controls was conducted. Genotypes of TSC gene 1784C/T and 2736G/A polymorphisms were analyzed by gene chip technology.

RESULTS

The genotype (1784C/T CC, CT, TT:87, 88, 15 vs 36, 52, 6û2736G/A GG, AG, AA:167, 22, 1 vs 83, 10, 1) and alleles frequency (1784C/T C, T:68.9%, 31.1% vs 66.0%, 34.0%; 2736G/A G,A:93.7%, 6.3% vs 93.6%, 6.4%) distribution of 1784C/T and 2736G/A showed no significant difference between the EH group and the control group (P >0.05). Moreover, no significant difference was observed in the frequencies distribution of four haplotypes (P > 0.05); Logistic regression analysis of haplotypes showed that the risk of EH had no significant difference in the population with different haplotypes (P > 0.05).

CONCLUSION

The 1784C/T and 2736G/A polymorphisms of TSC gene may not play an important role in the etiology of EH in a Han nationality population. The studies in the future are warranted to validate our findings.

摘要

目的

探讨噻嗪类敏感的钠氯共转运体（TSC）基因1784C/T和2736G/A多态性与汉族人群原发性高血压（EH）风险的相关性。

方法

进行一项基于社区的病例对照研究，纳入190例EH患者和94例性别及年龄匹配的对照。采用基因芯片技术分析TSC基因1784C/T和2736G/A多态性的基因型。

结果

1784C/T和2736G/A的基因型（1784C/T CC、CT、TT：87、88、15 对 36、52、6；2736G/A GG、AG、AA：167、22、1 对 83、10、1）及等位基因频率（1784C/T C、T：68.9%、31.1% 对 66.0%、34.0%；2736G/A G、A：93.7%、6.3% 对 93.6%、6.4%）在EH组和对照组之间分布无显著差异（P>0.05）。此外，四种单倍型的频率分布也无显著差异（P>0.05）；单倍型的Logistic回归分析显示，不同单倍型人群中EH风险无显著差异（P>0.05）。