Department of Histopathology, Central Manchester and Manchester Children's University Hospital NHS Trust, Manchester, UK.
Diagn Pathol. 2007 Dec 8;2:47. doi: 10.1186/1746-1596-2-47.
This short report discusses a case of neurofibroma containing floret-like multinucleated giant cells. This being the second such case in the literature. Floret-like multinucleated giant cells have been reported in gynaecomastia and neurofibroma in neurofibromatosis type 1. These cells have been reported in uncommon soft tissue tumours including pleomorphic lipoma, giant cell collagenoma, giant cell fibroblastoma and giant cell angiofibroma. We recommend these cells to be interpreted carefully keeping in mind the rare malignant change in neurofibromas. Immunohistochemistry would help in defining the nature of such cells.
本短篇报告讨论了一例含有小花状多核巨细胞的神经纤维瘤。这是文献中第二例此类病例。小花状多核巨细胞已在男性乳腺发育症和神经纤维瘤病 1 型的神经纤维瘤中报道过。这些细胞也已在罕见的软组织肿瘤中报道过，包括多形性脂肪瘤、巨细胞胶原瘤、巨细胞成纤维细胞瘤和巨细胞血管纤维瘤。我们建议在考虑到神经纤维瘤罕见的恶性变化时，仔细解读这些细胞。免疫组织化学有助于确定这些细胞的性质。
