雪貂（Mustela putorius furo）多系统肉芽肿性病变中1型冠状病毒抗原的鉴定。

Martínez J, Reinacher M, Perpiñán D, Ramis A

Departament de Sanitat i Anatomia Animals, Facultat de Veterinària, Universitat Autònoma de Barcelona, Barcelona, Spain.

J Comp Pathol. 2008 Jan;138(1):54-8. doi: 10.1016/j.jcpa.2007.10.002. Epub 2007 Dec 11.

Tissues from nine ferrets with granulomatous lesions similar to those seen in feline infectious peritonitis were examined histopathologically and immunohistochemically. Four main types of lesions were observed: diffuse granulomatous inflammation on serosal surfaces; granulomas with areas of necrosis; granulomas without necrosis; and granulomas with neutrophils. Other less commonly seen lesions were granulomatous necrotizing vasculitis and endogenous lipid pneumonia. FCV3-70 monoclonal antibody produced immunolabelling of group 1 coronavirus antigen in tissue samples from eight animals, the antigen being present in the cytoplasm of macrophages in the different types of granulomatous lesions.

对9只雪貂的组织进行了组织病理学和免疫组织化学检查，这些雪貂的肉芽肿性病变与猫传染性腹膜炎中所见的病变相似。观察到四种主要类型的病变：浆膜表面的弥漫性肉芽肿性炎症；伴有坏死区域的肉芽肿；无坏死的肉芽肿；以及伴有中性粒细胞的肉芽肿。其他较少见的病变是肉芽肿性坏死性血管炎和内源性脂质肺炎。FCV3-70单克隆抗体在8只动物的组织样本中产生了1型冠状病毒抗原的免疫标记，该抗原存在于不同类型肉芽肿性病变的巨噬细胞胞质中。