Kipar A, Kremendahl J, Addie D D, Leukert W, Grant C K, Reinacher M
Institut für Veterinär-Pathologie, Universität Leipzig, Germany.
J Comp Pathol. 1998 Jul;119(1):1-14. doi: 10.1016/s0021-9975(98)80067-4.
This report describes five cases of naturally occurring feline coronavirus enteritis. The affected animals, aged 2 months to 7 years, had a clinical history of intestinal symptoms, including diarrhoea or vomiting, or both. They exhibited variable histological changes in the epithelium of the small intestine, ranging from degeneration of single cells and detachment of groups of cells from the villous tips to regenerative processes of the crypt epithelia. Post-mortem diagnosis was based on the immunohistochemical demonstration of coronavirus antigen within intestinal epithelial cells and on the electron microscopical demonstration of coronavirus particles in the faeces. In addition, one animal was immunohistochemically positive for antigens of feline leukaemia virus (FeLV) and exhibited intestinal changes consistent with FeLV-associated enteritis. Two cats were tested serologically for feline immunodeficiency antibodies, with negative results. The findings indicate that natural coronavirus infection is a potential cause of severe enteritis in juvenile and adult cats.
本报告描述了5例自然发生的猫冠状病毒肠炎病例。受影响的动物年龄在2个月至7岁之间，有肠道症状的临床病史，包括腹泻或呕吐，或两者皆有。它们在小肠上皮表现出不同的组织学变化，从单个细胞的变性和绒毛顶端细胞群的脱离到隐窝上皮的再生过程。尸检诊断基于肠道上皮细胞内冠状病毒抗原的免疫组织化学证明以及粪便中冠状病毒颗粒的电子显微镜证明。此外，一只动物猫白血病病毒（FeLV）抗原免疫组织化学呈阳性，并表现出与FeLV相关肠炎一致的肠道变化。对两只猫进行了猫免疫缺陷抗体的血清学检测，结果为阴性。这些发现表明，自然冠状病毒感染是幼年和成年猫严重肠炎的一个潜在原因。
