de Jong Frank Jan, Vernooij Meike W, Ikram M Kamran, Ikram M Arfan, Hofman Albert, Krestin Gabriel P, van der Lugt Aad, de Jong Paulus T V M, Breteler Monique M B
Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, Netherlands.; Department of Neurology, Erasmus Medical Center, Rotterdam, Netherlands.
Ophthalmology. 2008 May;115(5):887-92. doi: 10.1016/j.ophtha.2007.06.036. Epub 2007 Dec 11.
Retinal vessel diameters, in particular larger venular diameters, have been associated with cerebrovascular disease. Larger retinal venular diameters may reflect cerebral ischemia. The authors investigated whether arteriolar oxygen saturation (SaO2) and total cerebral blood flow (CBF), indicators of cerebral oxygen supply, are associated with retinal arteriolar or venular diameters.
Cross-sectional study performed within the population-based Rotterdam Study.
Randomly selected participants aged 55 years or older (n = 696), who underwent both an eye examination and brain magnetic resonance imaging (MRI).
Arteriolar oxygen saturation was determined by pulse oximetry on the right index finger. Cerebral blood flow was assessed using a phase-contrast MRI sequence that measured the flow in the basilar and both internal carotid arteries. Brain volume was measured to express CBF per 100 ml brain volume. Retinal arteriolar and venular diameters were measured on digitized fundus color transparencies on 1 eye of each participant. Regression models were used to investigate the association of SaO(2) and CBF with retinal vessel diameters.
Mean retinal arteriolar and venular diameters (in micrometers).
Lower SaO2 was associated with larger venular diameters. Persons with SaO(2) less than 96% (n = 113) had on average 5 microm larger venular diameters compared with those with SaO(2) of 96% or more (n = 583; age- and gender-adjusted mean difference, 5.6 microm; 95% confidence interval, 1.2-10.0). Cerebral blood flow was not related to venular diameters when analyzed separately. Additional analyses showed that the association between SaO(2) and venular widening was confined to participants within the lowest tertile of CBF. No associations were found between SaO(2) or CBF and arteriolar diameters. Additional adjustment for established cardiovascular risk factors did not change the results.
An association of lower SaO(2) with larger retinal venular diameters was observed, in particular in the presence of lower CBF. These findings suggest that venular widening may reflect a lower oxygen supply, especially to the brain.
视网膜血管直径，尤其是较大的静脉直径，已被证实与脑血管疾病有关。较大的视网膜静脉直径可能反映脑缺血。作者研究了作为脑氧供应指标的动脉血氧饱和度（SaO2）和全脑血流量（CBF）是否与视网膜动脉或静脉直径相关。
在基于人群的鹿特丹研究中进行的横断面研究。
随机选取年龄在55岁及以上的参与者（n = 696），他们均接受了眼部检查和脑磁共振成像（MRI）。
通过对右手食指进行脉搏血氧测定来确定动脉血氧饱和度。使用相位对比MRI序列评估脑血流量，该序列测量基底动脉和双侧颈内动脉的血流。测量脑容量以表示每100 ml脑容量的CBF。在每位参与者一只眼睛的数字化眼底彩色透明片上测量视网膜动脉和静脉直径。使用回归模型研究SaO(2)和CBF与视网膜血管直径之间的关联。
视网膜动脉和静脉的平均直径（以微米为单位）。
较低的SaO2与较大的静脉直径相关。SaO(2)低于96%的人（n = 113）与SaO(2)为96%或更高的人（n = 583）相比，静脉直径平均大5微米；年龄和性别调整后的平均差异为5.6微米；95%置信区间为1.2 - 10.0。单独分析时，脑血流量与静脉直径无关。进一步分析表明，SaO(2)与静脉增宽之间的关联仅限于CBF最低三分位数的参与者。未发现SaO(2)或CBF与动脉直径之间存在关联。对已确定的心血管危险因素进行额外调整并未改变结果。
观察到较低的SaO(2)与较大的视网膜静脉直径相关，尤其是在CBF较低的情况下。这些发现表明静脉增宽可能反映了较低的氧供应，特别是对大脑的氧供应。
