[Effect of glutathione on brain energy metabolism in antenatal hypoxia].

The authors studied the effect of reduced glutathione and its combination with sodium succinate, which are used during intrauterine development, on the energy metabolism in the mitochondria of the cortex and stem part of the brain, as well as the spasmodic readiness of young rats after antenatal exposure to hypoxic hypoxia. It was found that the effect of antenatal hypoxia causes disorders of oxidative phosphorylation in the brain mitochondria and increases the spasmodic readiness of the offsprings. In animals who were exposed to antenatal hypoxia and given the mentioned agents, compensation of the disturbed oxidative phosphorylation and reduced spasmodic readiness were encountered.