Maĭzelis M Ia, Zabludovskiĭ A L, Shikhov S N
Zh Nevropatol Psikhiatr Im S S Korsakova. 1983;83(3):74-9.
The development and preservation of conditioned reflexes of passive and active avoidance, behaviour in "the open field", as well as the sensitivity to spasmodic agents were investigated in rats that had suffered acute intrauterine hypoxia, perinatal asphyxia, and exposure to ethanol in the antenatal period. The findings obtained were correlated with the parameters of protein biosynthesis which were considerably altered in some brain structures of the experimental animals. It is suggested that disturbances in protein metabolism in the central nervous system play an important role in the development of long-term manifestations of the deleterious action of pathogenic factors on the developing brain in the antenatal period.
对遭受急性宫内缺氧、围产期窒息以及产前暴露于乙醇的大鼠，研究了其被动和主动回避条件反射的形成与保持、在“旷场”中的行为以及对致痉挛剂的敏感性。所获结果与实验动物某些脑结构中显著改变的蛋白质生物合成参数相关。提示中枢神经系统蛋白质代谢紊乱在产前致病因素对发育中大脑有害作用的长期表现发展中起重要作用。
