Onarheim H, Reed R K, Laurent T C
Department of Physiology, University of Bergen, Norway.
Scand J Clin Lab Invest. 1991 Dec;51(8):693-7. doi: 10.3109/00365519109104582.
Hyaluronan (HYA) is a polysaccharide found in the interstitial matrix in most tissues. HYA is removed by lymphatic drainage and degraded in local lymph nodes and in the liver. Its normal concentration in human plasma is very low (10-100 micrograms l-1). Following major burn injury in sheep plasma HYA can increase to levels tenfold greater than normal. In the present study, serum HYA concentrations were determined in 10 severely burned patients (burn size: 28 +/- 5% of body surface area (mean +/- SEM)). Serum HYA concentration was 206 +/- 71 micrograms l-1 at 24 h post-injury, twice the upper normal HYA concentration, and remained moderately elevated for the first week post-injury. It appears that mobilization and transport of HYA from the tissues is increased after thermal injury. Increased systemic concentrations of an interstitial matrix component have not previously been reported in burn patients. Possibly, plasma concentrations of connective tissue components might serve as indicators of the severity and extent of burn injuries.
透明质酸（HYA）是一种存在于大多数组织间质基质中的多糖。HYA通过淋巴引流被清除，并在局部淋巴结和肝脏中降解。其在人体血浆中的正常浓度非常低（10 - 100微克/升）。绵羊遭受严重烧伤后，血浆中的HYA可增加至比正常水平高十倍的浓度。在本研究中，测定了10例严重烧伤患者（烧伤面积：占体表面积的28±5%（平均值±标准误））的血清HYA浓度。受伤后24小时血清HYA浓度为206±71微克/升，是正常HYA浓度上限的两倍，并且在受伤后的第一周一直保持中度升高。热损伤后似乎从组织中动员和运输的HYA有所增加。此前尚未有关于烧伤患者间质基质成分全身浓度增加的报道。结缔组织成分的血浆浓度可能作为烧伤严重程度和范围的指标。
